There will always be a segment of society, all societies, that will choose to that which is prohibited simply because it IS prohibited. That's one of my arguments for legalization of all drugs. If that one draw factor alone is eliminated it would seemingly also take away the "getting away with something" ideology that leads some people to do anything society/laws deem as illegal.

To Robs point, if science were capable of making all drugs effects moot, another group of enterprising individuals would wind up working just as diligently to undo such results and could possibly even find a way to not only over-ride such a chemical blocking within the body but also possibly manage to intensify drugs reactions within a body because of it ..... BONUS

Legalize and regulate ALL drugs. To do otherwise is nothing short of legislating views of morality and historically that's never been proven to be effective over the tests of time.

While those who drink alcohol reside all smug and safe in the confines of their "legal" drug of choice, here's some food for thought, An interesting article I read some months back pointed out that if alcohol as an intoxicant were discovered today and the effects of alcoholic beverages on the human body were as well documented as they are today, it would never have been legalized for consumption